Amira Announces The Successful Completion Of GLP Toxicity Studies For A Novel DP2 Antagonist
Add commentsdiscovered oral drug candidate for the treatment and control of inflammatory
and allergic diseases linked to the arachidonic acid pathway, is on target
for submission of an IND to the U.S. Food and Drug Administration (FDA) by
mid-2009 following the successful completion of Good Laboratory Practices
(GLP) toxicity studies.
AM211 is an oral, selective antagonist of the receptor DP2 (also known as
lymphocytes). DP2 is a high affinity receptor for prostaglandin (PG) D2 and,
studies have shown that a DP2 antagonist has the potential to be an oral
allergic rhinitis.
effective in several inflammatory/allergic models," said Peppi Prasit, PhD,
pharmacodynamics in preclinical models and its safety profile, we believe
that AM211 has the potential to be an exciting next generation, once a day
oral medication for respiratory diseases including COPD. In addition, we have
a structurally distinct backup compound, AM461, about to enter GLP toxicity
and early drug development. For the second time in as many programs, Amira is
on track to enter human studies within two years from program start," said
Bob Baltera, Amira’s Chief Executive Officer. "These are exciting times at
Amira as our team continues to demonstrate world-class capabilities in drug
Founded in 2005 and headquartered in San Diego, Amira Pharmaceuticals is
a small molecule pharmaceutical company focused on the discovery and early
phospholipid pathways. Amira has a strategic partnership with GlaxoSmithKline
for the development of FLAP (5-lipoxygenase activating protein) inhibitors in
respiratory and cardiovascular disease.
efficient and effective pre-clinical and clinical program decisions. Its
scientific founders have successfully worked together for more than a decade
including generic lasix online buy Singulair(R). The drug hunters at Amira are now actively leveraging
their history of success to create high-value compounds for the future.
View drug information on Singulair.
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